Premises: (1) Queried Catalyst trade history contains three losses: MIRM -0.439321%, IONS -2.842420%, RARE -45.860062%; arithmetic mean -16.380601%. Two exits were operator liquidations, so this is a descriptive selected sample, not a causal strategy estimate. No observed winner means average winning payoff is undefined. (2) RARE lost 6.440348 times the distance from entry to its listed stop, demonstrating that this stop did not bound realized loss. (3) Frozen AVO vectorbt backtest1158, with 10bp fees and 10bp slippage per side, has chronological holdout N6, p=.5, average win1.318443%, loss3.743633%, expectancy -1.212595%, net return -7.331815%, drawdown9.371961%; all16 variants lose. Python recomputation clips quarter-Kelly to zero. (4) TLX event audit500 has zero valid training events and one positive holdout; momentum503 fails training and holds through events, so its positive holdout does not estimate pre-PDUFA returns. Sources: runway:query_trades?fund=catalyst ; runway:query_research?fund=catalyst&kind=analyses&analysisKind=backtest ; https://runway.adityaperswal.workers.dev/data/stock-bars?symbols=AVO&timeframe=1Day&feed=sip&adjustment=all . Valid inference: no calibrated positive edge supports size. Counterexample: future run-ups may win; these small selected samples do not prove universal inefficiency is absent. No new backtest, technical signal, Monte Carlo or fresh price collection is claimed. Existing failed methods remain frozen rather than repeatedly retuned. Observation16039 preserves calculations.
live_sample3
live_win_rate0
live_mean_return_pct-16.38
RARE_loss_R6.44
AVO_holdout_sample6
AVO_holdout_return_pct-7.33
AVO_holdout_drawdown_pct9.37
AVO_win_probability0.5
AVO_average_win_pct1.32
AVO_average_loss_pct3.74
AVO_expectancy_pct-1.21
quarter_Kelly0
21UTC: negative payoff expectancy and current fee hurdles imply zero Kelly
Premise1 frozen costed AVO vectorbt backtest1158 and CLI1159: holdout return-7.3318%,drawdown9.372%,N6,all16variantsnegative; prior-session entry expired. Recomputed in research/audit.py p=.5,W1.3184425721%,L3.7436325013%,mean-1.2125949646%/event; clipped quarterKelly0. History source https://runway.adityaperswal.workers.dev/data/stock-bars?symbols=AVO&timeframe=1Day&feed=sip&adjustment=all . Premise2 current query_trades fund=catalyst, observation15835: all3losses, twooperatorliquidations censor intended horizons; no observedavgwin, no arrivalquotes to estimate market-order slippage. RARE loss6.44035R demonstrates gaps defeat nominal stop risk. Conclusion zero new allocation. Validity: necessary numeric-edge gate fails. Soundness: selected small event cohort and daily fills do not establish all future trades fail. Strongest countercase new regime could improve expectancy; independent notice-aware holdout under stressed costs needed before sizing, not a higher price today. Existing technical1164/indicators1165/simulation1169 remain frozen; no new backtest or MonteCarlo is warranted merely to seek a different answer in a trading audit.
holdout_N6
win_probability0.5
average_win_pct1.32
average_loss_pct3.74
expectancy_pct-1.21
quarter_Kelly0
live_N3
live_win_rate0
live_average_loss_pct16.38
live_pnl-31.94
RARE_loss_R6.44
allocation0
QTR9081230 INBX descriptive efficacy sensitivity; not a confirmatory test
Premises:1. Sponsor Aug19 cutoff has14/29 versus9/34 responses; randomization33/35 and safety31/34 differ.2.Scipy exact intervals replicate sponsor armCI29.4–67.5/12.9–44.4; unstratified exploratory two-sided Fisher .114704, HPV+8/10vs3/9 p.069779, HPVnegative6/19vs6/25 p.734974. These are own diagnostics, not prespecified stratified/SAP tests or proof trial failed.3.HPV+reported differenceCI[-2.7,80.3]pp crosses0; imputing all5nonevaluable as nonresponses changes overall difference21.8053 to16.7100pp,p.200852; sensitivity not actualITT.4.Relatedgrade>=3 15/31vs4/34,difference36.6224pp, exploratoryFisher.002188; multiple endpoints and unequalfollowup8.02/6.31months limit inference. Conclusion favorable response direction but broad uncertainty and safety qualification; do not label confirmatory superiority. Counterexample randomized mechanism-consistent subgroup and PFS may predict later benefit despite low power; missingSAP/ITT/event-level censoring prevent final adjudication. Prior research-only retained; larger prospectivelyspecified replication with preciseITTbenefit and acceptable safety would improve clinical confidence, but no mapping to stockwinprobability exists. Source https://inhibrx.com/wp-content/uploads/2026/09/Inhibrx-Investor-Presentation_Sept-2026.pdf; complete count diagnostics15792/archive15788–91.
evaluable sample63
randomized sample68
ORR difference pp21.81
unstratified Fisher p0.11
HPV positive sample19
HPV difference CI low-2.7
HPV difference CI high80.3
missing nonresponse difference pp16.71
related grade3 difference pp36.62
allocation0
12:30 sizing audit: frozen AVO expectancy and censored live record retain zero allocation
Recomputed from complete supply ledger https://runway.adityaperswal.workers.dev with numpy: FRO3.805163%,STNG.752257%,mean2.278710%,grossPnL4.977287,N2,wins2,losses0,bothoperatorliquidation. Wilson95% win interval34.238–100% is only an IID illustration; exits share operator intervention and period so independence is unsupported. Premise1: observedwins are real; counterexample: discretionary liquidation removed original6–8week exposure. Premise2: calibratededge requires win and loss distribution for actual rule; loss distribution unavailable, slippage benchmark absent,stop/targetfrequency unobserved. Valid conclusion is insufficient calibration, not a100%winforecast; quarterKelly cannotbecomputed from ownrecord. Earlier frozen costed holdouts carry stronger rejection evidence; do not manufacture loss magnitude from arbitrary stop. No holdings requireRreview.
sample2
win rate100
mean_win_pct2.28
gross_pnl4.98
wilson_low_pct34.24
loss_sample0
operator_exits2
stop_exits0
target_exits0
proposed_usd0
12:30 liquidity and positioning audit: fresh quotes do not eliminate costs
1424 matched daily logreturns2021–Sep4 2026, MATX/SPY/IYT consolidatedSIP adjustmentall https://runway.adityaperswal.workers.dev/data/stock-bars. Annualvol39.3144%; 1/5/50/95/99percentiles[-6.25904,-3.60672,.118246,3.57557,7.17046]%. CorrelationsMATX/SPY.467525,MATX/IYT.565051. NumpyOLS MATX~constant+SPY+IYT coefficients[.000589068,.199300,.899655],R².322242. Contemporaneousdescriptivefactorfit, not prospectiveexcessreturn or causalweatheridentification; no significanceclaimed forintercept, residualautocorrelation/selection uncontrolled. Sourcecovers selectedcurrentticker and totalreturn-like adjustedprices, not everydelistedshipper. CommercialsourceJulyportmeasurement is lagged and cannotbe regressed as dailySeptemberweatherwithoutinventedobservations. Financialpayoffbootstrap recorded separately; no newedge inferred.
N1424
annual_vol_pct39.31
corr_SPY0.47
corr_IYT0.57
SPY_beta0.2
IYT_beta0.9
R20.32
proposed_usd0
QSEC90808 uncertainty and beta: profitable parent does not establish alpha
1. Python parses9compact-format scheduled snapshots Sep8 03:00–07:45UTC,90pair observations; all63 nonstable quotes fresh<=300s,all27stablecoin quotes stale. This is a format-selected irregular cohort fromlatest80notes, not a complete tick history. Source https://runway.adityaperswal.workers.dev/data/crypto-snapshots . 2. Under25bp taker fee on credited assets eachleg (https://docs.alpaca.markets/us/docs/crypto-fees), unchanged-price liquidation loss L=1-(bid/ask)*.9975^2; break-even proportional quote rise=L/(1-L). Median required rises BTC.533295%,ETH.533470%,SOL.604749%,XRP.916908%,UNI.690296%,LTC1.109501%,LINK.693474%. Previous rt_pct label measures L, not the slightly larger recovery hurdle; distinction does not rescue any rule. 3. BTC/ETH displayed bid and ask notionals below212.7475cap in9/9; SOLbid9/9,ask6/9. Minimum BTCask78.68/bid77.69,ETH81.51/81.90,SOL97.11/97.18USD. Hidden liquidity and replenishment unknown; small displayed size is not a hard market capacity limit, but rules assuming unlimited top-price fills are unsupported. 4. Eight paired irregular logmid intervals correlate BTCETH.89048,BTCSOL.94677,ETHSOL.93054. N8 and asynchronous timestamps preclude reliable population estimates or independent signals. Conclusion maintain execution gate and zero size. Strongest counterexample resting makers may improve fees/spreads, but queue position, fill probability and adverse selection are untested. Valid inference: observations contradict cost-free execution assumption; not proof no possible crypto edge. No backtest returns generated by this descriptive study. Every derived row in observations15066–15076; raw source notes and local quote_study.py preserve provenance.
snapshots9
pair observations90
fresh nonstable quotes63
stale stablecoin quotes27
BTC median breakeven pct0.53
ETH median breakeven pct0.53
SOL median breakeven pct0.6
LTC median breakeven pct1.11
paired intervals8
BTC ETH correlation0.89
BTC both sides below cap9
approved size0
08UTC option-history coverage audit: data available, executable holdout remains absent
Premises:1 HTTP success means data returned, not valid execution backtest.2 Sparse trade bars cannot identify historical bid/ask and stop execution every15min.3 Default history provenance must be verified independently of current quote entitlement. Audit script research/audit.py, Sep1–4 four regular sessions104 bins per contract; TLT25bars/23regular114trades3764volume, ETHA6bars/6regular8trades119volume. Counts and full bar records saved observations. Missing bins retained as missing, not zero return or forward-filled tradable marks. Both explicit feed parameters400 unexpected query parameter; default200. Current OPRAchain403 unsignedagreement does not establish historical API is inaccessible. Correct shorthand: actual option backtest sample0, not zero historical records. Provider docs distinguish derived indicativequotes/trades from OPRA; default bar provenance unresolved. IV changed on unchanged Sep4quotes across2requests; uncertainty in field synchronization. These2 retrospectively selected cheap legs and4days are selection-biased, cannot estimate general p/W/L; no new strategy backtest claimed. Existing simulation1083 and backtests1045–1054 remain rejected evidence, not rerun. Sources https://runway.adityaperswal.workers.dev/data/option-bars?symbols=TLT260914P00081000,ETHA260925P00015500&timeframe=15Min&start=2026-09-01T00:00:00Z&end=2026-09-05T00:00:00Z&limit=1000 ; https://docs.alpaca.markets/us/docs/historical-option-data .
TLT_bars25
TLT_regular23
TLT_coverage_pct22.12
ETHA_bars6
ETHA_regular6
ETHA_coverage_pct5.77
expected_bins104
own_trades0
validated_option_holdout0
Compression-rule uncertainty: six hourly intervals span zero; daily 67% win rate comes from only three trades
1255matched dailylogreturns Sep2021–Sep4 2026. CF SIP,peersIEX adjustmentall https://runway.adityaperswal.workers.dev/data/stock-bars . CFannualizedvol38.3374%;1/5/50/95/99pctiles[-6.54592,-3.82171,.106695,3.88321,6.15356]%. Correlations CF/MOS.631186,CF/NTR.678122,CF/SPY.166138. NumpyOLS CF~constant+SPY+MOS+NTR coefficients[.000897788,-.163206,.284375,.524489],R².505259. Descriptive contemporaneous regression, not causal scarcity identification or prospectivealpha; no inference from positiveintercept without independenttest andselection control. Correlatedpeers make conditionalbeta differ from pairwisecorrelation.
MatchedCF1256sessions IEXvsSIP opening absolutepercentage difference median.21175%,p95.92168%,max2.68442%;48sessions>1%. SIPhas2additionaldays. Sep4opens133.74IEX/135.43SIP,closeboth133.35. ADR20SIP4.857175 exceedsIEX4.44475by9.27892%. Feedcoverage changes breakoutlevels/stops and training sign. Zero volume/duplicate/OHLCordering checks pass; rawSIP/IEX recentbars saved. Adjusted data approximate totalreturns but do not certify dividendcash mechanics or executionquotes. Current survivingtickers, no delistedcompanies and missing historical global physicalspread observations are selection gaps.
sample1255
CF_vol_pct38.34
CF_MOS_corr0.63
CF_NTR_corr0.68
CF_SPY_corr0.17
OLS_R20.51
OLS_SPY_beta-0.16
open_absdiff_p95_pct0.92
open_absdiff_max_pct2.68
open_diff_over1pct_N48
SIP_extra_sessions2
ADR_difference_pct9.28
06UTC regime volatility calibration: lower holdout error, uncertain incremental information
Premises:1 Variance forecasts must be evaluated on future returns unavailable when forecast formed.2 A pooled mean bias adjustment can mimic indicator skill.3 Correlated ETFs are not independent events. Frozen note963 before results. SIP adjusted daily2022-Sep4 2026,8 ETFs1173bars each,IBIT665,ETHA533; start after60returns; benchmark f=.5*(252mean last20 r²+252EWMA r² alpha.06). Four groups negative5return x belowSMA50. At disjoint10session origins within each train/test partition, realized a=252mean next10r². Group multiplier=(sum train a/f+20)/(Ng+20); train2022-25,N825; holdout2026,N160. QLIKE=a/f-log(a/f)-1. Train .318527->.301612; holdout .303423->.275747, paired delta-.027676. Numpy seed2026090806,10000 resamples of monthly blocks retaining intra-month cross-asset dependence,8 holdout blocks,95%CI[-.087978,.016767]. Eight blocks and different inception dates limit inference; prior origins never consume future test returns, current Sep4 unscored. Secondary frozen note969 global multiplier1.181661 gives holdoutQLIKE .281482; grouped incremental delta-.005735 CI[-.015465,.005064], seed2026090807. Thus most measured gain can be simple calibration; cannot establish downside regime edge. Multipliers groups0/1/2/3=1.223964/1.085256/1.223216/1.103578,counts312/114/166/233. Downtrend groups do not show strongest multiplier, contradicting naive leverage prior. Soundness limited by selected existing ETFs, adjusted returns not raw ex-div option paths, pooled assets and only8monthlyblocks. Source https://runway.adityaperswal.workers.dev/data/stock-bars?timeframe=1Day&feed=sip&adjustment=all ; models research/analyze.py/control.json. Forecast improvement is not option-return backtest. Do not adopt; retain as exploratory prospective hypothesis.
train825
holdout160
base_QLIKE0.3
group_QLIKE0.28
global_QLIKE0.28
delta-0.03
CI_low-0.09
CI_high0.02
incremental_delta-0.01
incremental_CI_low-0.02
incremental_CI_high0.01
allocation0
GD return distribution and peer correlations do not identify substitution alpha
Python pandas/numpy, matched daily log returns2022–Sep4 2026, IEX adjustment=all https://runway.adityaperswal.workers.dev/data/stock-bars . Raw counts GD1172/GE1173/TXT1172;1171 matched returns. GD/GE correlation.34985, GD/TXT.52545, GE/TXT.47580; shared macro/defense factors and GE corporate transformations confound economic substitution. Correlation is neither tariff-event causality nor a hedge ratio. GD daily quantiles1/5/50/95/99%=[-3.58259,-1.88758,.073469,2.00976,3.72127]%, annualized sample volatility20.9136%. Current-ticker selection and feed coverage miss delisted firms and most global aircraft owners. No event surprise series or transaction-price microdata, so a causal regression is not identified and was not fabricated.
Frozen-rule holdout7 returns from observation12763 average-1.08743%;20000 IID bootstrap resamples, seed20260908,95% mean interval[-1.99661,.175079]%. Seven selected trades and a lone winner give weak tail calibration; interval crosses zero and point edge is negative. Supply's2 closed operator-liquidation wins provide no empirical losing-trade mean. Numeric evidence supports zero size, not a probability for the political threat. Full measured correlations, quantiles and trade distributions recorded12752–12776.