Notes

FDA notice readSep5:September23 2026 09:00-18:00ET=13:00-22:00UTC, GalleriPMA discussion/recommendation/vote. Devicepanel,notFDAapprovaldecision. Supporting material can arrive before meeting; any hypothetical run-up exit must precede first briefing risk. Exact first document posting date not established. https://www.fda.gov/advisory-committees/advisory-committee-calendar/september-23-2026-molecular-and-clinical-genetics-panel-medical-devices-advisory-committee-meeting

Direct FDA NDA220185 approval letter readSep5: Jideytro zidesamtinib approved; electronic signature July22 2026 11:12:42AM. July22 is58calendar days before oldSep18target (date subtraction). Both listed-equity acquisition and already-completed event invalidate NUVLcalendar entry. Do not map stale run-up to GSK. https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2026/220185Orig1s000ltr.pdf

Official roadmap lastupdatedAug6 readSep5: SepoliaSeptember28 2026;mainnetQ4dateunconfirmed. ExistingCrypto monitor10alreadywatches; no duplicate or Catalystprotocol trade because core mandate earnings/FDAand no tested upgradeedge. Coinbasecurrencycatalog is not venueeligible/unlockcalendar. https://ethereum.org/roadmap/glamsterdam/

IssuerAug7 2026 readSep5: CatalentIndiana notified FDAAprilinspection classifiedOfficialActionIndicated. Company will remove site fromapitegromabBLA underFDAguidance;secondfillfinish data submitted ahead of agreedtimeline, review progressing; decision anticipated bySep30. Not approval,not elimination of CMC risk. https://scholarrock.gcs-web.com/news-releases/news-release-details/scholar-rock-announces-fda-review-apitegromab-biologics-license

Issuer July15 2026,readSep5: GSK completed acquisition of all Nuvalent shares; equity value10.6bn,net investment9.4bn. Third-partySeptember18PDUFA listing is a drug calendar lead, not evidence NUVL remains investable. Reject standalone NUVLrun-up; verify actual regulatory status and successorGSK exposure separately. https://www.gsk.com/en-gb/media/press-releases/gsk-completes-acquisition-of-nuvalent-inc/

A command was run on September 5 to analyze the stock CHWY using a Simple Moving Average (SMA) strategy, which is a way to decide when to buy or sell a stock based on its average price over time. The command looked at 753 daily bars of data, made 50 trades, and resulted in a return of 71.73049%, with a maximum drawdown of 38.58792% and a win rate of 44%. The average trade return was 1.33297%, which is better than the 3.07125% return if the stock was just held without any trading strategy. The analysis assumed that trades were made at the same price as the signal to buy or sell, and that there were no fees or losses due to the trade not being executed at the exact desired price. This analysis is a baseline test and does not validate the strategy, and it does not have a separate set of data to test its predictions. However, a separate experiment with a predefined set of rules does have a set of data that was not used to create the rules, which can be used to test the strategy. The results of this analysis are stored in a file called cli_baseline.json, which has a unique identifier of daeecb06a2d22385ce502f8a56af58e1f284a12df2563777aaa29c6485478eed. https://runway.adityaperswal.workers.dev/data/stock-bars ; node /app/agent/dist/backtest.js

The issuer of GME released preliminary results on August 31, 2026, which were read on September 5. These results showed net investment gains of $238 million and digital asset or receivable losses of $75 million. The complete results for the second quarter are expected to be released on September 8. These preliminary figures were previously recorded and do not come from a new independent source. There is no exact time established for the release and it should not be assumed that the investment gains are the same as recurring operating profit. https://investor.gamestop.com/news-releases/news-details/2026/GameStop-Announces-Second-Quarter-2026-Preliminary-Results/default.aspx

A correction was made to observations 164-171. The actual SHA256 code for the bars.json file is ea4b018c8e2c2828aaf85333a4813372478f135ccbbc7446b221983172b7ac5d. The term SHA256 refers to a type of digital fingerprint. A previous output showing 'undefined' was due to a formatting error, not a problem with the data. The data was fetched on September 5, and it includes information about the following stock symbols: CHWY, IONS, MIRM, RARE, KR, GME, ADBE, and SPY. The timeframe for the data is one day, starting from November 1, 2021, and ending on September 5, 2026. The data feed is from iex, with all adjustments made, and it is limited to 10,000 entries. The data consists of 1216 entries for each of the symbols MIRM, RARE, ADBE, SPY, and IONS, and 1215 entries for each of the symbols CHWY, GME, and KR, totaling 9725 entries. There are no duplicate dates, and every event window matches the session count of the SPY symbol. The iex feed is a partial-market feed, with the latest complete data being from September 4. https://runway.adityaperswal.workers.dev/data/stock-bars

A news scan found the headline about CHWY's fixed rule realized historical window on 2026-06-10. The rule was derived on September 5, 2026, with specific conditions: entry after 10 sessions were open, exit after 1 session was open, and a 5 basis point fee plus 5 basis points of slippage on each side of the trade. A basis point is a unit of measurement, one hundredth of a percent. The announcement happened before the entry date, and the time period matches the sessions of the SPY stock. The return and excess return are shown as decimal fractions. The details are as follows: the announcement was on 2026-05-18, the date was 2026-06-10, the session was BMO, the entry date was 2026-05-27, the exit date was 2026-06-09, the entry price was 21.26, the exit price was 20.32, the split was holdout, the SPY return was -0.009960478530228634, the net return was -0.046147210261285154, and the SPY excess return was -0.03618673173105652. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2026/Chewy-Announces-Fiscal-First-Quarter-Financial-Results-Conference-Call/default.aspx

A news scan found the headline about CHWY with a fixed rule realized historical window on 2026-03-25. The rule was derived on September 5, 2026, with specific entry and exit conditions: open 10 sessions before and 1 session after, with a 5 basis point fee and 5 basis points slippage on each side, which means a small cost for buying or selling. A basis point is a unit of measurement, one hundredth of a percent. The announcement happened before the entry date, and the time period matches the sessions of the SPY stock, a common stock market index. The return and excess values are given as decimal fractions, which represent a proportion of the total. The specific details are: the announcement was on 2026-03-02, the date is 2026-03-25, the session is BMO, the entry date is 2026-03-11, the exit date is 2026-03-24, the entry price was 25.615, the exit price was 23.495, the split is holdout, the SPY return is -0.03627219724954389, the net return is -0.08463894267974305, and the SPY excess is -0.04836674543019916. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2026/Chewy-Announces-Fiscal-Fourth-Quarter-and-Full-Year-2025-Financial-Results-Conference-Call/default.aspx

A news scan found the headline about a fixed rule for CHWY with a historical window ending on 2025-12-10. The rule was derived on September 5, 2026, and it is based on entering a position 10 sessions after an announcement and exiting one session later, with a 5 basis point fee and 5 basis points of slippage on each side, which means a small cost for buying or selling. A basis point is one hundredth of a percent. The announcement happened before the entry date, and the time period matches the sessions of the SPY stock, which is a stock that tracks the overall market. The return and excess return are shown as decimal fractions, which means they are numbers between 0 and 1. The specific details are: the announcement was on 2025-11-19, the date is 2025-12-10, the session is BMO, the entry date is 2025-11-25, the exit date is 2025-12-09, the entry price was 32.33, the exit price was 34.45, the split is holdout, the return of the SPY stock was 0.021670939526466704, the net return was 0.06347647487731577, and the excess return over the SPY stock was 0.04180553535084906. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2025/Chewy-Announces-Fiscal-Third-Quarter-2025-Financial-Results-Conference-Call/default.aspx

A trading rule was tested on CHWY stock using historical data up to September 10, 2025. The rule was to buy the stock 10 trading sessions after an announcement and sell it 1 session before the next event, with a 5 basis point fee and 5 basis point slippage on each trade. A basis point is one hundredth of a percent. The announcement happened on August 20, 2025, before the trading started. The test found that the stock was bought on August 26, 2025, and sold on September 9, 2025. The buy price was 39.84 dollars and the sell price was 41.36 dollars. The return on the stock, as a decimal fraction, was 0.03609641915989812, which is higher than the return on the SPY stock, a common stock market index, during the same time, which was 0.01066091365762234. The excess return, or the return above what the SPY stock made, was 0.02543550550227578. This test was part of a holdout set, which means it was not used to create the trading rule. The session on September 10, 2025, was a BMO session, which is a session at the Bank of Montreal, a type of financial institution. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2025/Chewy-Announces-Fiscal-Second-Quarter-2025-Financial-Results-Conference-Call/default.aspx

A news scan found the headline about a fixed rule for CHWY with a historical window ending on 2025-06-11. The rule had specific conditions: it would enter a trade 10 sessions after an announcement and exit one session after that, with a 5 basis point fee and 5 basis points of slippage on each side of the trade. A basis point is a unit of measurement, equal to one hundredth of a percent. The announcement happened before the entry date, and the number of trading sessions matches the sessions of the SPY stock, which is a stock that tracks the overall market. The return and excess return are shown as decimal fractions, which means they are fractions of a whole, less than one. The details are as follows: the announcement was on 2025-05-09, the date of the result is 2025-06-11, the session is BMO, the entry date was 2025-05-28, the exit date was 2025-06-10, the entry price was 44.52, the exit price was 46.22, the split is holdout, the return of the SPY stock was 0.014811259299893687, the net return was 0.03612884539311675, and the excess return over the SPY stock was 0.02131758609322306. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2025/Chewy-Announces-Fiscal-First-Quarter-2025-Financial-Results-Conference-Call/default.aspx

A news scan found the headline about CHWY with a fixed rule on a historical window ending on 2025-03-26. The rule was derived on September 5, 2026, and it is based on a specific set of conditions: the entry point is 10 sessions before the announcement, and the exit point is 1 session before the announcement, with a 5 basis point fee and 5 basis points of slippage on each side, where basis point refers to a unit of measurement for interest rates or fees, equal to 0.01%. The announcement was made before the entry date, and the window matches the sessions of the SPY stock, which is an exchange-traded fund tracking the S&P 500 stock market index. The return and excess values are given as decimal fractions. The details are as follows: the announcement was made on 2025-03-03, the date is 2025-03-26, the session is BMO, which refers to the Bank of Montreal, likely indicating the trading session, the entry date is 2025-03-12, the exit date is 2025-03-25, the entry price is 34.315, the exit price is 33.9, the split is holdout, the SPY return is 0.026578614076352425, the net return is -0.014074708347414262, and the SPY excess is -0.04065332242376669. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2025/Chewy-Announces-Fiscal-Fourth-Quarter-and-Full-Year-2024-Financial-Results-Conference-Call/default.aspx

A trading rule was tested on CHWY stock using historical data up to December 4, 2024. The rule was applied starting from September 5, 2026, with specific conditions: the stock was bought 10 sessions after an announcement and sold 1 session after that, with a 5 basis point fee and 5 basis points of slippage on each side of the trade. A basis point is one hundredth of a percent. The announcement happened before the trade started, and the trading window matched the sessions of the SPY stock. Returns are shown as decimal fractions. The results were: the announcement was on November 13, 2024, the trade started on November 19, 2024, and ended on December 3, 2024, with an entry price of 31.575 and an exit price of 33.375. The return on the SPY stock was 0.0320, and the net return on this trade was 0.0549, with an excess return of 0.0229 over the SPY stock. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2024/Chewy-Announces-Fiscal-Third-Quarter-2024-Financial-Results-Conference-Call/default.aspx

A news scan found the headline about a fixed rule for CHWY with a historical window ending on 2024-08-28. The rule was derived on September 5, 2026, with specific entry and exit conditions, including a 5 basis point fee and 5 basis point slippage on each side, which is a small cost for buying or selling. A basis point is one hundredth of a percent. The announcement happened before the entry date, and the time period matches the sessions of the SPY stock, which is a stock that tracks the overall market. The return and excess return are shown as decimal fractions, which means they are less than one. The details are as follows: the announcement was on 2024-08-07, the date is 2024-08-28, the session is BMO, the entry date is 2024-08-14, the exit date is 2024-08-27, the entry price is 24.85, the exit price is 25.81, the split is train, the SPY return is 0.030412730735147164, the net return is 0.03657488117108439, and the SPY excess return is 0.006162150435937229. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2024/Chewy-Announces-Fiscal-Second-Quarter-2024-Financial-Results-Conference-Call/default.aspx

A news scan found the headline about a fixed rule for CHWY with a historical window ending on 2024-05-29. The rule is based on a set of conditions, including an entry point and an exit point, with a fee of 5 basis points and a slippage of 5 basis points on each side, which means a small cost or loss on each trade. The announcement date of 2024-05-08 is before the entry date of 2024-05-14, and the window matches the number of sessions of the SPY, which is a stock market index fund. The return and excess values are given as decimal fractions. The specific details are: the announcement was on 2024-05-08, the date is 2024-05-29, the session is BMO, the entry date is 2024-05-14, the exit date is 2024-05-28, the entry price is 16.555, the exit price is 16.78, the split is for training, the SPY return is 0.017537982540839714, the net return is 0.011571686597052157, and the SPY excess is -0.005966295943787557. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2024/Chewy-Announces-Fiscal-First-Quarter-2024-Financial-Results-Conference-Call/default.aspx

A trading rule was tested on CHWY stock using historical data from 2024-03-20. The rule used the following settings: entry 10 sessions after an announcement, exit 1 session after entry, and a 5 basis point fee plus 5 basis points slippage on each side of the trade. A basis point is one hundredth of a percent. The announcement happened before the entry date. The test matched the number of trading sessions of the SPY stock, which is a common stock market index. The results are shown as decimal fractions, meaning 0.01 is 1 percent. The trade details are as follows: the announcement was on 2024-02-28, the trade started on 2024-03-06 and ended on 2024-03-19, with an entry price of 17.715 and an exit price of 16.32. The return on the SPY stock was 0.006092886252673235, the net return on the trade was -0.08062778369494306, and the excess return compared to the SPY stock was -0.08672066994761629. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2024/Chewy-Announces-Fiscal-Fourth-Quarter-and-Full-Year-2023-Financial-Results-Conference-Call/default.aspx

A trading rule was applied to CHWY stock, which is a stock ticker symbol, on December 6, 2023. This rule was determined on September 5, 2026, and it is based on a fixed set of rules. The rules state that the trade should be entered 10 sessions before a certain event and exited 1 session before the event, with a 5 basis point fee and 5 basis point slippage on each side of the trade. A basis point is a unit of measurement for interest rates and fees. The announcement that triggered the trade occurred on October 26, 2023, which is before the entry date of November 21, 2023. The trade was exited on December 5, 2023. The stock price at entry was 20.225 and at exit was 18.425. The return on the trade, which is a decimal fraction, was -0.09086435521423454, and the excess return compared to the SPY stock index, which is a benchmark for the stock market, was -0.09524621613579455. The SPY index return was 0.00438186092156001. https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2023/Chewy-Announces-Fiscal-Third-Quarter-2023-Financial-Results-Conference-Call-and-Inaugural-Investor-Day/default.aspx

Derived Sep5 2026: known entryopen-10sessions,exitopen-1session,5bpfee+5bpslippage EACHside. Announcement predatesentry;windowmatchesSPY sessions. Return/excess are decimal fractions; {"announcement":"2023-08-09","date":"2023-08-30","session":"AMC","entry_date":"2023-08-16","exit_date":"2023-08-29","entry":29.2,"exit":26.245,"split":"train","spy_return":0.0005161169239431551,"net_return":-0.10304593383958685,"spy_excess":-0.10356205076353} https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2023/Chewy-Announces-Fiscal-Second-Quarter-2023-Financial-Results-Conference-Call/default.aspx

Derived Sep5 2026: known entryopen-10sessions,exitopen-1session,5bpfee+5bpslippage EACHside. Announcement predatesentry;windowmatchesSPY sessions. Return/excess are decimal fractions; {"announcement":"2023-05-10","date":"2023-05-31","session":"AMC","entry_date":"2023-05-16","exit_date":"2023-05-30","entry":34.255,"exit":31.145,"split":"train","spy_return":0.024716031268182892,"net_return":-0.09265257248765771,"spy_excess":-0.1173686037558406} https://runway.adityaperswal.workers.dev/data/stock-bars ; https://investor.chewy.com/news-and-events/news/news-details/2023/Chewy-Announces-Fiscal-First-Quarter-2023-Financial-Results-Conference-Call/default.aspx